研究活動
原著論文
2014
Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7
Keisuke Fukunaga, Takaaki Hatanaka, Yuji Ito, Michiko Minami and Masumi Taki
Chem. Commun., 30, 3887-4012 (2014).
Pharmacophore Generation from a Drug-like Core Molecule Surrounded by a Library Peptide via the 10BASEd-T on Bacteriophage T7
Tokunaga, Y., Azetsu, Y., Fukunaga, Y., Hat-anaka T., Ito, Y. and Taki, M.
Molecules, 19, 2481-2496 (2014).
Selection and characterization of human serum albumin-specific porcine scFv antibodies using a phage display library
Muraoka, J., Ozawa, T., Enomoto, Y., Kiyose, N. Imamura, A., Arima, K. Nakayama, H. and Ito, Y.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 33, 42-48 (2014).
2013
Gp10 based-thioetherification (10BASEd-T) on a displaying library peptide of bacteriophage T7
Keisuke Fukunaga, Takaaki Hatanaka, Yuji Ito, Masumi Taki
Molecular BioSystems, 9, 2988-2991 (2013).
Preparation and evaluation of cellulose-dissolving magnetic ionic liquid
Muraoka, J., Kamiya, N., and Ito, Y.
Journal of Molecular Liquids, 182, 76-78 (2013).
2012
Isolation and affinity maturation of human IgA-specific peptide from random peptide T7 phage library for designing a new IgA affinity ligand
Takaaki Hatanaka, Shogo Tsukamoto, Kotaro Sakamoto, Kazunari Arima and Yuji Ito
Peptide Science, 2011, 25-26 (2012).
Human IgA-binding peptides selected from random peptide libraries: affinity maturation and application in IgA purification
Takaaki Hatanaka, Shinji Ohzono, Mirae Park, Shogo Tsukamoto, Ryohei Sugita, Kotaro Sakamoto, Hiroyuki Ishitobi, Toshiyuki Mori, Osamu Ito, Koichi, Sorajo, Kazuhisa Sugimura, Sihyun Ham, Yuji Ito
The Journal of biological chemistry, Dec 14;287(51), 43126-36 (2012).
2011
mimotope peptide of Abeta42 fibril-specific antibodies with Abeta42 fibrillation inhibitory activity induces anti-Abeta42 conformer antibody response by a displayed form on an M13 phage in mice
Tanaka, K., Nishimura, M., Yamaguchi, Y., Hashiguchi, S., Takiguchi, S., Yamaguchi, M., Tahara, H., Gotanda, T., Abe, R., Ito, Y., Sugimura, K. A
J Neuroimmunol., 236, 27-38 (2011).
2010
Characterization of human single-chain antibodies against highly pathogenic avian influenza H5N1 viruses: mimotope and neutralizing activity
Yang, J., Yoshida, R., Kariya, Y., Zhang, X., Hashiguchi, S., Nakashima, T., Suda, Y., Takada, A., Ito, Y., Sugimura, K.
Journal of biochemistry, 148, 507-515 (2010).
2009
Regulation of T cell response by blocking the ICOS signal with the B7RP-1-specific small antibody fragment isolated from human antibody phage library
Maeda, M., Ito, Y., Hatanaka, T., Hashiguchi, S., Torikai, M., et al.
mAb, 1, 450-457 (2009).
Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions
Sakamoto K., Ito Y., Hatanaka T., Soni P.B., Mori T. and Sugimura K.
The Journal of biological chemistry, 284, 9986-9993 (2009).
Generation of recombinant monoclonal antibodies against an immunodominant HLA-A*2402-restricted HIV-1 CTL epitope
Nunoya J., Nakashima T., Kawana-Tachikawa A., Kiyotahi K., Ito Y., Sugimura K., Iwamoto A.
AIDS research and human retroviruses, 25, 897-904 (2009).
Effective Induction of Cell Death on Adult T-Cell Leukemia Cells by HLA-DR {beta}-Specific Small Antibody Fragment Isolated From Human Antibody Phage Library.
Muraoka S., Ito Y*., Kamimura M., Baba M., Arima N., Suda Y., Hashiguchi S., Torikai M., Nakashima T. and Sugimura K.
Journal of biochemistry, 145, 799-810 (2009).
High sensitivity analysis of naturally occurring sugar-chains, using a novel fluorescent linker molecule
Sato M., Ito Y., Arima N., Baba M., Sobel M., Wakao M. and Suda Y
Journal of biochemistry, 146, 33-41 (2009).
Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction
Takeda S., Ishii Y., Iwanaga M., Nurrochmad A., Ito Y., Mackenzie P.I., Nagata K., Yamazoe Y., Oguri K. and Yamada H.
Molecular pharmacology, 75, 956-964 (2009).
Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells
Baba M., Okamoto M., Hamasaki T., Horai S., Wang X., Ito Y., Suda Y. and Arima N.
Molecular pharmacology, 75, 956-964 (2009).
2008
Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system
Honjo E., Shoyama Y., Tamada T., Shigematsu H., Hatanaka T., Kanaji S., Arima K., Ito Y., Izuhara K. and Kuroki R.
Protein expression and purification, 60, 25-30 (2008).
Ig L-chain shuffling for affinity maturation of phage library-derived human anti-human MCP-1 antibody blocking its chemotactic activity
Yoshinaga K., Matsumoto M., Torikai M., Sugyo K., Kuroki S., Nogami K., Matsumoto R., Hashiguchi S., Ito Y., Nakashima T. Sugimura K.
Journal of biochemistry, 143, 593-601 (2008).
Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro
Yoshihara T., Takiguchi S., Kyuno A., Tanaka K., Kuba S., Hashiguchi S., Ito Y., Hashimoto T., Iwatsubo T., Tsuyama S., Nakashima, T., Sugimura, K.
Journal of biochemistry, 143, 475-486 (2008).
2007
Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro
Hamasaki T., Uchida S., Yoshihara T., Hashiguchi S., Ito Y., Sugimura K.
Biological & pharmaceutical bulletin, 30, 1361-1364 (2007).
2006
Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes
Sakamoto K., Ito Y., Mori T. and Sugimura K.
The Journal of biological chemistry, 281, 24472-24478 (2006).
2005
Human anti-human IL-18 antibody recognizing the IL-18-binding site 3 with IL-18 signaling blocking activity
Hamasaki T., Hashiguchi S., Ito Y., Kato Z., Nakanishi K., Nakashima T. and Sugimura K.
Journal of biochemistry, 138, 433-442 (2005).
The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
Abeyama K.*, Stern D.M., Ito Y., Kawahara K., Yoshimoto Y., Tanaka M., Uchimura T., Ida N., Yamazaki Y., Yamada S., Yamamoto, Y.,Yamamoto, H., Iino, S., Taniguchi, N., Maruyama, I.
The Journal of clinical investigation, 115, 1267-1274 (2005).
2004
Molecular characterization of a 10-kDa buckwheat molecule reactive to allergic patients' IgE.
Matsumoto R., Fujino K., Nagata Y., Hashiguchi S., Ito Y., Aihara Y., Takahashi Y., Maeda K. and Sugimura K.
Allergy, 59, 533-538 (2004).
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